BAIT
RNF10
RIE2
ring finger protein 10
GO Process (5)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
DHX36
DDX36, G4R1, MLEL1, RHAU
DEAH (Asp-Glu-Ala-His) box polypeptide 36
GO Process (8)
GO Function (10)
GO Component (4)
Gene Ontology Biological Process
- ATP catabolic process [IBA, IDA]
- RNA processing [IBA]
- RNA secondary structure unwinding [IDA]
- innate immune response [TAS]
- ossification [ISS]
- positive regulation of telomere maintenance [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of type I interferon production [TAS]
Gene Ontology Molecular Function- ATP-dependent RNA helicase activity [IBA]
- DNA-dependent ATPase activity [IDA]
- G-quadruplex DNA binding [IDA]
- G-quadruplex RNA binding [IMP]
- core promoter binding [IDA]
- double-stranded RNA binding [IDA]
- histone deacetylase binding [ISS]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- transcription regulatory region DNA binding [ISS]
- ATP-dependent RNA helicase activity [IBA]
- DNA-dependent ATPase activity [IDA]
- G-quadruplex DNA binding [IDA]
- G-quadruplex RNA binding [IMP]
- core promoter binding [IDA]
- double-stranded RNA binding [IDA]
- histone deacetylase binding [ISS]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- transcription regulatory region DNA binding [ISS]
Homo sapiens
Protein-RNA
An interaction is detected between and protein and an RNA in vitro.
Publication
CircRNF10 triggers a positive feedback loop to facilitate progression of glioblastoma via redeploying the ferroptosis defense in GSCs.
Glioma exhibit heterogeneous susceptibility for targeted ferroptosis. How circRNAs alterations in glioma promote iron metabolism and ferroptosis defense remains unclarified.The highly enriched circRNAs in glioblastoma (GBM) were obtained through analysis of sequencing datasets. Quantitative real-time PCR (qRT-PCR) was used to determine the expression of circRNF10 in glioma and normal brain tissue. Both gain-of-function and loss-of-function studies were used to assess ... [more]
J Exp Clin Cancer Res Sep. 19, 2023; 42(1);242 [Pubmed: 37723588]
Throughput
- High Throughput
Additional Notes
- Bait is circRNF10
Curated By
- BioGRID