BAIT
RNF10
RIE2
ring finger protein 10
GO Process (5)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
VIL1
D2S1471, VIL
villin 1
GO Process (17)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- actin filament capping [IDA]
- actin filament depolymerization [IDA]
- actin filament polymerization [IDA]
- actin filament severing [IDA]
- cellular response to epidermal growth factor stimulus [IDA]
- cytoplasmic actin-based contraction involved in cell motility [IDA]
- epidermal growth factor receptor signaling pathway [IDA]
- epithelial cell differentiation [IEP]
- positive regulation of actin filament bundle assembly [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of epithelial cell migration [IDA]
- protein complex assembly [TAS]
- regulation of actin nucleation [IDA]
- regulation of cell shape [IDA]
- regulation of lamellipodium morphogenesis [ISS]
- regulation of wound healing [ISS]
- response to bacterium [IDA]
Gene Ontology Molecular Function- actin filament binding [IDA]
- calcium ion binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISS]
- identical protein binding [IPI]
- lysophosphatidic acid binding [IDA]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- actin filament binding [IDA]
- calcium ion binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISS]
- identical protein binding [IPI]
- lysophosphatidic acid binding [IDA]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
Protein-RNA
An interaction is detected between and protein and an RNA in vitro.
Publication
CircRNF10 triggers a positive feedback loop to facilitate progression of glioblastoma via redeploying the ferroptosis defense in GSCs.
Glioma exhibit heterogeneous susceptibility for targeted ferroptosis. How circRNAs alterations in glioma promote iron metabolism and ferroptosis defense remains unclarified.The highly enriched circRNAs in glioblastoma (GBM) were obtained through analysis of sequencing datasets. Quantitative real-time PCR (qRT-PCR) was used to determine the expression of circRNF10 in glioma and normal brain tissue. Both gain-of-function and loss-of-function studies were used to assess ... [more]
J Exp Clin Cancer Res Sep. 19, 2023; 42(1);242 [Pubmed: 37723588]
Throughput
- High Throughput
Additional Notes
- Bait is circRNF10
Curated By
- BioGRID