BAIT
RNF10
RIE2
ring finger protein 10
GO Process (5)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
CACTIN
C19orf29, NY-REN-24, fSAPc
cactin, spliceosome C complex subunit
GO Process (12)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- cellular response to interleukin-1 [IDA]
- cellular response to lipopolysaccharide [IDA]
- cellular response to tumor necrosis factor [IDA]
- mRNA splicing, via spliceosome [IC]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of interferon-beta production [IMP]
- negative regulation of interleukin-8 production [IDA]
- negative regulation of lipopolysaccharide-mediated signaling pathway [IMP]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of toll-like receptor signaling pathway [IDA]
- negative regulation of tumor necrosis factor production [IDA]
- negative regulation of type I interferon-mediated signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Protein-RNA
An interaction is detected between and protein and an RNA in vitro.
Publication
CircRNF10 triggers a positive feedback loop to facilitate progression of glioblastoma via redeploying the ferroptosis defense in GSCs.
Glioma exhibit heterogeneous susceptibility for targeted ferroptosis. How circRNAs alterations in glioma promote iron metabolism and ferroptosis defense remains unclarified.The highly enriched circRNAs in glioblastoma (GBM) were obtained through analysis of sequencing datasets. Quantitative real-time PCR (qRT-PCR) was used to determine the expression of circRNF10 in glioma and normal brain tissue. Both gain-of-function and loss-of-function studies were used to assess ... [more]
J Exp Clin Cancer Res Sep. 19, 2023; 42(1);242 [Pubmed: 37723588]
Throughput
- High Throughput
Additional Notes
- Bait is circRNF10
Curated By
- BioGRID