BAIT
RNF10
RIE2
ring finger protein 10
GO Process (5)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
EIF2AK3
PEK, PERK, WRS
eukaryotic translation initiation factor 2-alpha kinase 3
GO Process (26)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- ER overload response [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- angiogenesis [IMP]
- bone mineralization [ISS]
- calcium-mediated signaling [ISS]
- cellular protein metabolic process [TAS]
- cellular response to glucose starvation [IMP]
- chondrocyte development [ISS]
- endocrine pancreas development [IMP]
- endoplasmic reticulum organization [ISS]
- endoplasmic reticulum unfolded protein response [IDA, TAS]
- insulin secretion [ISS]
- insulin-like growth factor receptor signaling pathway [ISS]
- negative regulation of myelination [ISS]
- negative regulation of translation [TAS]
- negative regulation of translational initiation in response to stress [TAS]
- ossification [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of transcription from RNA polymerase I promoter [IMP]
- positive regulation vascular endothelial growth factor production [IMP]
- protein autophosphorylation [IDA, IMP]
- protein homooligomerization [IMP]
- protein phosphorylation [ISS]
- response to endoplasmic reticulum stress [IMP]
- skeletal system development [ISS]
Gene Ontology Molecular Function
Homo sapiens
Protein-RNA
An interaction is detected between and protein and an RNA in vitro.
Publication
CircRNF10 triggers a positive feedback loop to facilitate progression of glioblastoma via redeploying the ferroptosis defense in GSCs.
Glioma exhibit heterogeneous susceptibility for targeted ferroptosis. How circRNAs alterations in glioma promote iron metabolism and ferroptosis defense remains unclarified.The highly enriched circRNAs in glioblastoma (GBM) were obtained through analysis of sequencing datasets. Quantitative real-time PCR (qRT-PCR) was used to determine the expression of circRNF10 in glioma and normal brain tissue. Both gain-of-function and loss-of-function studies were used to assess ... [more]
J Exp Clin Cancer Res Sep. 19, 2023; 42(1);242 [Pubmed: 37723588]
Throughput
- High Throughput
Additional Notes
- Bait is circRNF10
Curated By
- BioGRID