BAIT
RNF10
RIE2
ring finger protein 10
GO Process (5)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
PPARGC1A
LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
GO Process (32)
GO Function (12)
GO Component (3)
Gene Ontology Biological Process
- RNA splicing [TAS]
- androgen receptor signaling pathway [NAS]
- brown fat cell differentiation [TAS]
- cellular glucose homeostasis [NAS]
- cellular respiration [TAS]
- cellular response to oxidative stress [ISS]
- circadian regulation of gene expression [ISS]
- digestion [TAS]
- fatty acid oxidation [NAS]
- gluconeogenesis [NAS]
- mRNA processing [TAS]
- mitochondrion organization [NAS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of neuron death [IGI]
- positive regulation of ATP biosynthetic process [ISS]
- positive regulation of energy homeostasis [ISS]
- positive regulation of fatty acid oxidation [TAS]
- positive regulation of gluconeogenesis [TAS]
- positive regulation of histone acetylation [TAS]
- positive regulation of mitochondrion organization [IBA, ISS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of transcription, DNA-templated [IDA, NAS]
- protein complex assembly [TAS]
- protein stabilization [TAS]
- regulation of circadian rhythm [ISS]
- regulation of transcription, DNA-templated [IDA]
- respiratory electron transport chain [ISS]
- response to muscle activity [ISS]
- response to starvation [NAS]
- temperature homeostasis [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- DNA binding [ISS, TAS]
- RNA binding [TAS]
- RNA polymerase II transcription cofactor activity [TAS]
- androgen receptor binding [NAS]
- chromatin DNA binding [ISS]
- ligand-dependent nuclear receptor binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [TAS]
- ubiquitin protein ligase binding [IPI]
- DNA binding [ISS, TAS]
- RNA binding [TAS]
- RNA polymerase II transcription cofactor activity [TAS]
- androgen receptor binding [NAS]
- chromatin DNA binding [ISS]
- ligand-dependent nuclear receptor binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [TAS]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Protein-RNA
An interaction is detected between and protein and an RNA in vitro.
Publication
CircRNF10 triggers a positive feedback loop to facilitate progression of glioblastoma via redeploying the ferroptosis defense in GSCs.
Glioma exhibit heterogeneous susceptibility for targeted ferroptosis. How circRNAs alterations in glioma promote iron metabolism and ferroptosis defense remains unclarified.The highly enriched circRNAs in glioblastoma (GBM) were obtained through analysis of sequencing datasets. Quantitative real-time PCR (qRT-PCR) was used to determine the expression of circRNF10 in glioma and normal brain tissue. Both gain-of-function and loss-of-function studies were used to assess ... [more]
J Exp Clin Cancer Res Sep. 19, 2023; 42(1);242 [Pubmed: 37723588]
Throughput
- High Throughput
Additional Notes
- Bait is circRNF10
Curated By
- BioGRID