BAIT
CEACAM6
CD66c, CEAL, NCA
carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
GO Process (2)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CHP1
CHP, SLC9A1BP, Sid470p, p22, p24
calcineurin-like EF-hand protein 1
GO Process (24)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- cellular response to acidic pH [ISS]
- cytoplasmic microtubule organization [ISS]
- membrane docking [ISS]
- membrane fusion [ISS]
- membrane organization [ISS]
- microtubule bundle formation [ISS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of calcineurin-NFAT signaling cascade [IDA]
- negative regulation of phosphatase activity [IDA]
- negative regulation of protein autophosphorylation [ISS]
- negative regulation of protein import into nucleus [IDA]
- negative regulation of protein kinase activity [ISS]
- negative regulation of protein phosphorylation [ISS]
- negative regulation of protein ubiquitination [ISS]
- positive regulation of protein glycosylation [ISS]
- positive regulation of protein targeting to membrane [ISS]
- positive regulation of protein transport [ISS]
- positive regulation of sodium:proton antiporter activity [IDA, ISS]
- potassium ion transport [TAS]
- protein export from nucleus [ISS]
- protein stabilization [ISS]
- regulation of intracellular pH [IDA]
- regulation of neuron death [IMP]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Proteomic profiling reveals CEACAM6 function in driving gallbladder cancer aggressiveness through integrin receptor, PRKCD and AKT/ERK signaling.
Gallbladder cancer (GBC) presents as an aggressive malignancy with poor patient outcome. Like other epithelial cancers, the mechanisms of GBC cancer progression remain vague and efforts in finding targeted therapies fall below expectations. This study combined proteomic analysis of formalin-fixed paraffin-embedded (FFPE) GBC samples, functional and molecular characterization of potential oncogenes and identification of potential therapeutic strategies for GBC. We ... [more]
Cell Death Dis Oct. 28, 2024; 15(10);780 [Pubmed: 39468006]
Throughput
- High Throughput
Additional Notes
- BioID
- FC greater than 3.0, adj. p less than or equal to 0.05
Curated By
- BioGRID