BAIT

CAND1

TIP120, TIP120A

cullin-associated and neddylation-dissociated 1

GO Process (4)

GO Function (1)

GO Component (7)

Gene Ontology Biological Process

SCF complex assembly [IDA]

cell differentiation [IDA]

negative regulation of catalytic activity [IDA]

protein ubiquitination [IDA]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

cullin-RING ubiquitin ligase complex [IDA]

cytoplasm [IDA]

extracellular vesicular exosome [IDA]

nucleoplasm [IDA]

ubiquitin ligase complex [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB HPRD

Homo sapiens

PREY

POLR2L

RBP10, RPABC5, RPB10, RPB10beta, RPB7.6, hRPB7.6

polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa

GO Process (19)

GO Function (5)

GO Component (6)

Gene Ontology Biological Process

7-methylguanosine mRNA capping [TAS]

DNA repair [TAS]

RNA splicing [TAS]

gene expression [TAS]

innate immune response [TAS]

mRNA splicing, via spliceosome [TAS]

nucleotide-excision repair [TAS]

positive regulation of type I interferon production [TAS]

positive regulation of viral transcription [TAS]

regulation of transcription from RNA polymerase I promoter [TAS]

termination of RNA polymerase III transcription [TAS]

transcription elongation from RNA polymerase II promoter [TAS]

transcription elongation from RNA polymerase III promoter [TAS]

transcription from RNA polymerase I promoter [IBA]

transcription from RNA polymerase II promoter [IDA, TAS]

transcription from RNA polymerase III promoter [TAS]

transcription initiation from RNA polymerase II promoter [TAS]

transcription-coupled nucleotide-excision repair [TAS]

viral process [TAS]

Gene Ontology Molecular Function

DNA-directed RNA polymerase activity [TAS]
RNA polymerase I activity [IBA]
RNA polymerase II activity [IBA]
RNA polymerase III activity [IBA]
zinc ion binding [IBA]

Gene Ontology Cellular Component

DNA-directed RNA polymerase I complex [IBA]

DNA-directed RNA polymerase II, core complex [IDA]

DNA-directed RNA polymerase III complex [IBA]

nucleoplasm [TAS]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Cullin-associated and neddylation-dissociated protein 1 (CAND1) alleviates NAFLD by reducing ubiquitinated degradation of ACAA2.

Huang X, Liu X, Li X, Zhang Y, Gao J, Yang Y, Jiang Y, Gao H, Sun C, Xuan L, Zhao L, Song J, Bao H, Zhou Z, Li S, Zhang X, Lu Y, Zhong X, Yang B, Pan Z

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder with high morbidity and mortality. The current study aims to explore the role of Cullin-associated and neddylation-dissociated protein 1 (CAND1) in the development of NAFLD and the underlying mechanisms. CAND1 is reduced in the liver of NAFLD male patients and high fat diet (HFD)-fed male mice. CAND1 alleviates palmitate ... [more]

Nat Commun Aug. 01, 2023; 14(1);4620 [Pubmed: 37528093]

Throughput

High Throughput

Curated By

BioGRID