BAIT

DROSHA

ETOHI2, HSA242976, RANSE3L, RN3, RNASE3L, RNASEN
drosha, ribonuclease type III
Homo sapiens
PREY

RBM6

3G2, DEF-3, DEF3, HLC-11, NY-LU-12, g16
RNA binding motif protein 6
GO Process (1)
GO Function (3)
GO Component (0)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

Paraspeckle-independent co-transcriptional regulation of nuclear microRNA biogenesis by SFPQ.

Thivierge C, Bellefeuille M, Diwan SS, Dyakov BJA, Leventis R, Perron G, Najafabadi HS, Gravel SP, Gingras AC, Duchaine TF

MicroRNAs (miRNAs) play crucial roles in physiological functions and disease, but the regulation of their nuclear biogenesis remains poorly understood. Here, BioID on Drosha, the catalytic subunit of the microprocessor complex, reveals its proximity to splicing factor proline- and glutamine (Q)-rich (SFPQ), a multifunctional RNA-binding protein (RBP) involved in forming paraspeckle nuclear condensates. SFPQ depletion impacts both primary and mature ... [more]

Cell Rep Sep. 24, 2024; 43(9);114695 [Pubmed: 39250314]

Throughput

  • High Throughput

Additional Notes

  • BioID
  • High-confidence identification score (Bayesian false discovery rate [BFDR] less than or equal to 0.01

Curated By

  • BioGRID