SLITRK2
Gene Ontology Biological Process
DLG4
Gene Ontology Biological Process
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IMP]
- dendritic spine morphogenesis [IMP, ISO]
- establishment of protein localization [ISO, ISS]
- locomotory exploration behavior [ISO, ISS]
- negative regulation of receptor internalization [IDA]
- neuromuscular process controlling balance [ISO, ISS]
- neuronal ion channel clustering [TAS]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of excitatory postsynaptic membrane potential [IDA]
- positive regulation of synaptic transmission [IDA]
- protein complex assembly [ISO, ISS]
- protein localization to synapse [IMP, ISO]
- receptor localization to synapse [IMP]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IDA]
- regulation of grooming behavior [ISO, ISS]
- regulation of long-term neuronal synaptic plasticity [ISO, ISS]
- social behavior [ISO, ISS]
- synaptic vesicle maturation [ISO, ISS]
- vocalization behavior [ISO, ISS]
Gene Ontology Molecular Function- D1 dopamine receptor binding [IPI]
- P2Y1 nucleotide receptor binding [IPI]
- PDZ domain binding [IPI]
- acetylcholine receptor binding [IDA]
- beta-1 adrenergic receptor binding [IPI]
- glutamate receptor binding [IPI]
- ionotropic glutamate receptor binding [IPI, ISO]
- protein C-terminus binding [IPI, ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- receptor binding [IPI]
- scaffold protein binding [ISO, ISS]
- D1 dopamine receptor binding [IPI]
- P2Y1 nucleotide receptor binding [IPI]
- PDZ domain binding [IPI]
- acetylcholine receptor binding [IDA]
- beta-1 adrenergic receptor binding [IPI]
- glutamate receptor binding [IPI]
- ionotropic glutamate receptor binding [IPI, ISO]
- protein C-terminus binding [IPI, ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- receptor binding [IPI]
- scaffold protein binding [ISO, ISS]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [ISO, ISS]
- cell junction [ISO, ISS]
- cerebellar mossy fiber [ISO]
- cortical cytoskeleton [ISO]
- cytoplasm [ISO, ISS]
- dendrite [ISO]
- dendrite cytoplasm [IDA]
- dendritic spine [ISS]
- endoplasmic reticulum [ISO, ISS]
- excitatory synapse [IDA, ISO]
- extrinsic component of cytoplasmic side of plasma membrane [ISO, ISS]
- ionotropic glutamate receptor complex [ISO, ISS]
- juxtaparanode region of axon [IDA, ISO]
- membrane [IDA, ISO]
- neuron projection terminus [ISO, ISS]
- neuron spine [ISO, ISS]
- neuronal postsynaptic density [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA, ISO]
- synapse [IDA, ISO]
- synaptic membrane [ISO]
- synaptic vesicle [ISO, ISS]
- voltage-gated potassium channel complex [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Slitrk2 controls excitatory synapse development via PDZ-mediated protein interactions.
Members of the Slitrk (Slit- and Trk-like protein) family of synaptic cell-adhesion molecules control excitatory and inhibitory synapse development through isoform-dependent extracellular interactions with leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs). However, how Slitrks participate in activation of intracellular signaling pathways in postsynaptic neurons remains largely unknown. Here we report that, among the six members of the Slitrk family, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DLG4 SLITRK2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID