SLITRK2
Gene Ontology Biological Process
DLG3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [ISO]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- dendritic shaft [IDA]
- extracellular space [ISO]
- growth cone [IDA]
- neuronal cell body [IDA]
- plasma membrane [ISO]
- postsynaptic density [IDA, TAS]
- synapse [IDA]
- tight junction [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Slitrk2 controls excitatory synapse development via PDZ-mediated protein interactions.
Members of the Slitrk (Slit- and Trk-like protein) family of synaptic cell-adhesion molecules control excitatory and inhibitory synapse development through isoform-dependent extracellular interactions with leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs). However, how Slitrks participate in activation of intracellular signaling pathways in postsynaptic neurons remains largely unknown. Here we report that, among the six members of the Slitrk family, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID