BAIT

EXO5

C1orf176, DEM1, Exo V, hExo5
exonuclease 5
Homo sapiens
PREY

GPS1

COPS1, CSN1
G protein pathway suppressor 1
UPS Project
GO Process (4)
GO Function (2)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart.

Hambarde S, Tsai CL, Pandita RK, Bacolla A, Maitra A, Charaka V, Hunt CR, Kumar R, Limbo O, Le Meur R, Chazin WJ, Tsutakawa SE, Russell P, Schlacher K, Pandita TK, Tainer JA

Stalled DNA replication fork restart after stress as orchestrated by ATR kinase, BLM helicase, and structure-specific nucleases enables replication, cell survival, and genome stability. Here we unveil human exonuclease V (EXO5) as an ATR-regulated DNA structure-specific nuclease and BLM partner for replication fork restart. We find that elevated EXO5 in tumors correlates with increased mutation loads and poor patient survival, ... [more]

Mol Cell Jul. 15, 2021; 81(14);2989-3006.e9 [Pubmed: 34197737]

Throughput

  • Low Throughput

Curated By

  • BioGRID