DLG4
Gene Ontology Biological Process
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IMP]
- dendritic spine morphogenesis [IMP, ISO]
- establishment of protein localization [ISO, ISS]
- locomotory exploration behavior [ISO, ISS]
- negative regulation of receptor internalization [IDA]
- neuromuscular process controlling balance [ISO, ISS]
- neuronal ion channel clustering [TAS]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of excitatory postsynaptic membrane potential [IDA]
- positive regulation of synaptic transmission [IDA]
- protein complex assembly [ISO, ISS]
- protein localization to synapse [IMP, ISO]
- receptor localization to synapse [IMP]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IDA]
- regulation of grooming behavior [ISO, ISS]
- regulation of long-term neuronal synaptic plasticity [ISO, ISS]
- social behavior [ISO, ISS]
- synaptic vesicle maturation [ISO, ISS]
- vocalization behavior [ISO, ISS]
Gene Ontology Molecular Function- D1 dopamine receptor binding [IPI]
- P2Y1 nucleotide receptor binding [IPI]
- PDZ domain binding [IPI]
- acetylcholine receptor binding [IDA]
- beta-1 adrenergic receptor binding [IPI]
- glutamate receptor binding [IPI]
- ionotropic glutamate receptor binding [IPI, ISO]
- protein C-terminus binding [IPI, ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- receptor binding [IPI]
- scaffold protein binding [ISO, ISS]
- D1 dopamine receptor binding [IPI]
- P2Y1 nucleotide receptor binding [IPI]
- PDZ domain binding [IPI]
- acetylcholine receptor binding [IDA]
- beta-1 adrenergic receptor binding [IPI]
- glutamate receptor binding [IPI]
- ionotropic glutamate receptor binding [IPI, ISO]
- protein C-terminus binding [IPI, ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- receptor binding [IPI]
- scaffold protein binding [ISO, ISS]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [ISO, ISS]
- cell junction [ISO, ISS]
- cerebellar mossy fiber [ISO]
- cortical cytoskeleton [ISO]
- cytoplasm [ISO, ISS]
- dendrite [ISO]
- dendrite cytoplasm [IDA]
- dendritic spine [ISS]
- endoplasmic reticulum [ISO, ISS]
- excitatory synapse [IDA, ISO]
- extrinsic component of cytoplasmic side of plasma membrane [ISO, ISS]
- ionotropic glutamate receptor complex [ISO, ISS]
- juxtaparanode region of axon [IDA, ISO]
- membrane [IDA, ISO]
- neuron projection terminus [ISO, ISS]
- neuron spine [ISO, ISS]
- neuronal postsynaptic density [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA, ISO]
- synapse [IDA, ISO]
- synaptic membrane [ISO]
- synaptic vesicle [ISO, ISS]
- voltage-gated potassium channel complex [IDA]
GRIN2B
Gene Ontology Biological Process
- action potential [IMP]
- associative learning [IMP]
- behavioral fear response [ISO]
- behavioral response to pain [ISO]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [ISO]
- cation transmembrane transport [ISO]
- cation transport [ISO]
- cellular response to amino acid stimulus [IEP]
- cellular response to dsRNA [IEP]
- cellular response to growth factor stimulus [IEP]
- cellular response to lipid [IEP]
- cellular response to magnesium starvation [IEP]
- cellular response to manganese ion [IEP]
- cellular response to organic cyclic compound [IEP]
- cerebral cortex development [IEP]
- detection of mechanical stimulus involved in sensory perception of pain [ISO]
- fear response [ISO]
- hippocampus development [IEP]
- in utero embryonic development [ISO]
- ion transmembrane transport [IDA]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- learning [ISO]
- learning or memory [TAS]
- long-term memory [IEP]
- memory [IDA, ISO]
- multicellular organismal response to stress [IEP]
- positive regulation of cell death [IDA, IMP]
- positive regulation of glutamate secretion [IDA]
- positive regulation of synaptic transmission [IMP]
- receptor clustering [IDA]
- regulation of MAPK cascade [IMP]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of postsynaptic membrane potential [ISO]
- regulation of protein kinase A signaling [ISO]
- regulation of synaptic plasticity [ISO]
- response to amine [IEP]
- response to amphetamine [IEP]
- response to calcium ion [IEP]
- response to carbohydrate [IEP]
- response to cocaine [IEP]
- response to cytokine [IEP]
- response to electrical stimulus [IEP]
- response to ethanol [IEP, ISO]
- response to fungicide [IEP]
- response to growth hormone [IEP]
- response to magnesium ion [IEP]
- response to manganese ion [IEP]
- response to mechanical stimulus [IEP]
- response to methylmercury [IEP]
- response to organic cyclic compound [IEP]
- response to other organism [IEP]
- response to toxic substance [IEP]
- rhythmic process [IDA]
- sensory organ development [ISO]
- startle response [ISO]
- suckling behavior [ISO]
- synaptic transmission [ISO]
- synaptic transmission, glutamatergic [IBA]
Gene Ontology Molecular Function- D2 dopamine receptor binding [IPI]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, ISO]
- beta-catenin binding [IPI]
- calcium channel activity [ISO]
- cation channel activity [ISO]
- cell adhesion molecule binding [IPI]
- drug binding [IPI]
- extracellular-glutamate-gated ion channel activity [IDA]
- glycine binding [ISO]
- interleukin-1 receptor binding [IPI]
- ionotropic glutamate receptor activity [IDA]
- ionotropic glutamate receptor binding [IPI]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- receptor binding [IPI]
- zinc ion binding [IDA]
- D2 dopamine receptor binding [IPI]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, ISO]
- beta-catenin binding [IPI]
- calcium channel activity [ISO]
- cation channel activity [ISO]
- cell adhesion molecule binding [IPI]
- drug binding [IPI]
- extracellular-glutamate-gated ion channel activity [IDA]
- glycine binding [ISO]
- interleukin-1 receptor binding [IPI]
- ionotropic glutamate receptor activity [IDA]
- ionotropic glutamate receptor binding [IPI]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- receptor binding [IPI]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA, ISO]
- Z disc [IDA]
- cell surface [ISO]
- dendritic spine [IDA]
- membrane [ISO]
- neuron projection [IDA, ISO]
- neuronal postsynaptic density [ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA, ISO]
- presynaptic membrane [IDA, ISO]
- synapse [IDA, ISO, TAS]
- synaptic cleft [IDA]
- synaptic vesicle [ISO]
- terminal bouton [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Prenatal morphine alters the synaptic complex of postsynaptic density 95 with N-methyl-D-aspartate receptor subunit in hippocampal CA1 subregion of rat offspring leading to long-term cognitive deficits.
Infants who are passively exposed to morphine or heroin through their addicted mothers usually develop neurobiological changes. The postsynaptic density 95 (PSD-95) protein, a submembranous cytoskeletal specialization, is dynamically linked with N-methyl-d-aspartate receptors (NMDARs) to form a synaptic complex in postsynaptic neurons. This complex serves important neurobiological functions, including mammalian learning and memory. However, the effects of prenatal morphine exposure ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GRIN2B DLG4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| GRIN2B DLG4 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID