USP10
Gene Ontology Biological Process
Gene Ontology Molecular Function
FSCN1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The formin DAAM1 regulates the deubiquitinase activity of USP10 and integrin homeostasis.
The differentiation of fibroblasts into pathological myofibroblasts during wound healing is characterized by increased cell surface expression of ?v-integrins. Our previous studies found that the deubiquitinase (DUB) USP10 removes ubiquitin from ?v-integrins, leading to cell surface integrin accumulation, subsequent TGF?1 activation, and pathological myofibroblast differentiation. In this study, a yeast two-hybrid screen revealed a novel binding partner for USP10, the ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FSCN1 USP10 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID