WWC2
Gene Ontology Biological Process
Gene Ontology Molecular Function
AMOT
Gene Ontology Biological Process
- actin cytoskeleton organization [IMP]
- blood vessel endothelial cell migration [IMP]
- blood vessel morphogenesis [IMP]
- cell migration involved in gastrulation [IMP]
- cellular protein localization [IMP, ISO]
- chemotaxis [IMP]
- establishment of cell polarity involved in ameboidal cell migration [IMP]
- gastrulation with mouth forming second [IMP]
- hippo signaling [ISO]
- in utero embryonic development [IMP]
- negative regulation of GTPase activity [IMP]
- negative regulation of angiogenesis [ISO]
- negative regulation of vascular permeability [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of embryonic development [IMP]
- regulation of cell migration [ISO]
- regulation of small GTPase mediated signal transduction [IMP]
- vasculogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
WWC1/2 regulate spinogenesis and cognition in mice by stabilizing AMOT.
WWC1 regulates episodic learning and memory, and genetic nucleotide polymorphism of WWC1 is associated with neurodegenerative diseases such as Alzheimer's disease. However, the molecular mechanism through which WWC1 regulates neuronal function has not been fully elucidated. Here, we show that WWC1 and its paralogs (WWC2/3) bind directly to angiomotin (AMOT) family proteins (Motins), and recruit USP9X to deubiquitinate and stabilize ... [more]
Throughput
- Low Throughput
Additional Notes
- Source of WWC2 not clear
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AMOT WWC2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 3770496 |
Curated By
- BioGRID