BAIT
ANK2
ANK-2, LQT4, brank-2
ankyrin 2, neuronal
GO Process (36)
GO Function (7)
GO Component (11)
Gene Ontology Biological Process
- SA node cell action potential [ISS]
- SA node cell to atrial cardiac muscle cell communication [IMP]
- T-tubule organization [ISS]
- atrial cardiac muscle cell action potential [IMP]
- atrial cardiac muscle cell to AV node cell communication [ISS]
- atrial septum development [IMP]
- axon guidance [TAS]
- cellular calcium ion homeostasis [ISS]
- cellular protein localization [IGI]
- membrane depolarization during SA node cell action potential [TAS]
- positive regulation of calcium ion transmembrane transporter activity [ISS]
- positive regulation of calcium ion transport [ISS]
- positive regulation of cation channel activity [ISS]
- positive regulation of gene expression [IGI]
- positive regulation of potassium ion transmembrane transporter activity [ISS]
- positive regulation of potassium ion transport [ISS]
- protein localization to M-band [ISS]
- protein localization to T-tubule [ISS]
- protein localization to cell surface [ISS]
- protein localization to endoplasmic reticulum [IGI]
- protein localization to organelle [IGI]
- protein localization to plasma membrane [IGI, ISS]
- protein stabilization [ISS]
- regulation of calcium ion transmembrane transporter activity [ISS]
- regulation of calcium ion transport [IGI]
- regulation of cardiac muscle cell contraction [IGI]
- regulation of cardiac muscle contraction [IMP]
- regulation of cardiac muscle contraction by calcium ion signaling [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IGI, ISS]
- regulation of heart rate [IMP]
- regulation of heart rate by cardiac conduction [IMP, ISS]
- regulation of protein stability [IC]
- regulation of release of sequestered calcium ion into cytosol [IGI]
- regulation of ventricular cardiac muscle cell membrane repolarization [IMP]
- sarcoplasmic reticulum calcium ion transport [TAS]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CTNNA2
CAP-R, CAPR, CT114, CTNR
catenin (cadherin-associated protein), alpha 2
GO Process (9)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- axonogenesis [ISS]
- brain morphogenesis [ISS]
- dendrite morphogenesis [ISS]
- muscle cell differentiation [TAS]
- positive regulation of muscle cell differentiation [TAS]
- prepulse inhibition [ISS]
- radial glia guided migration of Purkinje cell [ISS]
- regulation of synapse structural plasticity [ISS]
- single organismal cell-cell adhesion [ISS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.
Autism spectrum disorders (ASDs) have been linked to genes with enriched expression in the brain, but it is unclear how these genes converge into cell-type-specific networks. We built a protein-protein interaction network for 13 ASD-associated genes in human excitatory neurons derived from induced pluripotent stem cells (iPSCs). The network contains newly reported interactions and is enriched for genetic and transcriptional ... [more]
Cell Genom Mar. 08, 2023; 3(3);100250 [Pubmed: 36950384]
Throughput
- High Throughput
Additional Notes
- log2 FC greater than 0 and FDR less than or equal to 0.1 as threshold for significant interactors
Curated By
- BioGRID