An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.

Pintacuda G, Hsu YH, Tsafou K, Li KW, Martin JM, Riseman J, Biagini JC, Ching JKT, Mena D, Gonzalez-Lozano MA, Egri SB, Jaffe J, Smit AB, Fornelos N, Eggan KC, Lage K

Autism spectrum disorders (ASDs) have been linked to genes with enriched expression in the brain, but it is unclear how these genes converge into cell-type-specific networks. We built a protein-protein interaction network for 13 ASD-associated genes in human excitatory neurons derived from induced pluripotent stem cells (iPSCs). The network contains newly reported interactions and is enriched for genetic and transcriptional ... [more]

Cell Genom Mar. 08, 2023; 3(3);100250 [Pubmed: 36950384]

Throughput

High Throughput

Additional Notes

log2 FC greater than 0 and FDR less than or equal to 0.1 as threshold for significant interactors

Curated By

BioGRID

Interaction Summary

DYRK1A

Gene Ontology Biological Process

Gene Ontology Molecular Function

non-membrane spanning protein tyrosine kinase activity [IDA]protein binding [IPI]protein kinase activity [TAS]protein self-association [ISS]protein serine/threonine kinase activity [ISS]protein tyrosine kinase activity [ISS]tau protein binding [ISS]

Gene Ontology Cellular Component

SCRN1