BAIT

CHD8

AUTS18, HELSNF1
chromodomain helicase DNA binding protein 8
Autism spectrum disorder (ASD) Project
Homo sapiens
PREY

PPP1R3F

HB2E, R3F
protein phosphatase 1, regulatory subunit 3F
GO Process (2)
GO Function (2)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.

Pintacuda G, Hsu YH, Tsafou K, Li KW, Martin JM, Riseman J, Biagini JC, Ching JKT, Mena D, Gonzalez-Lozano MA, Egri SB, Jaffe J, Smit AB, Fornelos N, Eggan KC, Lage K

Autism spectrum disorders (ASDs) have been linked to genes with enriched expression in the brain, but it is unclear how these genes converge into cell-type-specific networks. We built a protein-protein interaction network for 13 ASD-associated genes in human excitatory neurons derived from induced pluripotent stem cells (iPSCs). The network contains newly reported interactions and is enriched for genetic and transcriptional ... [more]

Cell Genom Mar. 08, 2023; 3(3);100250 [Pubmed: 36950384]

Throughput

  • High Throughput

Additional Notes

  • log2 FC greater than 0 and FDR less than or equal to 0.1 as threshold for significant interactors

Curated By

  • BioGRID