PRNP
Gene Ontology Biological Process
- axon guidance [TAS]
- cellular copper ion homeostasis [NAS]
- metabolic process [TAS]
- negative regulation of T cell receptor signaling pathway [ISS]
- negative regulation of activated T cell proliferation [ISS]
- negative regulation of calcineurin-NFAT signaling cascade [ISS]
- negative regulation of interferon-gamma production [ISS]
- negative regulation of interleukin-17 production [ISS]
- negative regulation of interleukin-2 production [ISS]
- negative regulation of protein phosphorylation [ISS]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISS]
- response to oxidative stress [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PLCB1
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [ISS]
- G2/M transition of mitotic cell cycle [ISS]
- activation of meiosis involved in egg activation [ISS]
- cerebral cortex development [ISS]
- glutamate receptor signaling pathway [ISS]
- inositol phosphate metabolic process [TAS]
- insulin-like growth factor receptor signaling pathway [ISS]
- interleukin-1-mediated signaling pathway [IDA]
- interleukin-12-mediated signaling pathway [IDA]
- interleukin-15-mediated signaling pathway [IDA]
- memory [ISS]
- negative regulation of monocyte extravasation [ISS]
- negative regulation of transcription, DNA-templated [ISS]
- phosphatidylinositol metabolic process [ISS]
- positive regulation of CD24 biosynthetic process [ISS]
- positive regulation of G1/S transition of mitotic cell cycle [ISS]
- positive regulation of GTPase activity [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of acrosome reaction [ISS]
- positive regulation of developmental growth [ISS]
- positive regulation of embryonic development [ISS]
- positive regulation of interleukin-12 production [ISS]
- positive regulation of myoblast differentiation [ISS]
- positive regulation of transcription, DNA-templated [ISS]
- regulation of G-protein coupled receptor protein signaling pathway [ISS]
- regulation of fertilization [ISS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Prion protein oligomers cause neuronal cytoskeletal damage in rapidly progressive Alzheimer's disease.
High-density oligomers of the prion protein (HDPs) have previously been identified in brain tissues of patients with rapidly progressive Alzheimer's disease (rpAD). The current investigation aims at identifying interacting partners of HDPs in the rpAD brains to unravel the pathological involvement of HDPs in the rapid progression.HDPs from the frontal cortex tissues of rpAD brains were isolated using sucrose density ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PRNP PLCB1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2842851 |
Curated By
- BioGRID