BAIT

E7

E7 protein, VE7_HPV11
Protein E7
Human Papilloma Virus (HPV) Project
GO Process (0)
GO Function (0)
GO Component (0)
Human papillomavirus (11)
PREY

MDK

ARAP, MK, NEGF2
midkine (neurite growth-promoting factor 2)
GO Process (6)
GO Function (2)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

HPV E7 inhibits cell pyroptosis by promoting TRIM21-mediated degradation and ubiquitination of the IFI16 inflammasome.

Song Y, Wu X, Xu Y, Zhu J, Li J, Zou Z, Chen L, Zhang B, Hua C, Rui H, Zheng Q, Zhou Q, Wang Q, Cheng H

Human papillomavirus (HPV) is a DNA virus that causes sexually transmitted infections. The HPV oncoprotein E7 plays a critical role in the regulation of host immunity to promote the immune escape of HPV and the occurrence of cervical cancer or genital warts. Pyroptosis, a highly inflammatory form of programmed cell death, can be induced by inflammasomes and acts as a ... [more]

Int J Biol Sci Oct. 17, 2020; 16(15);2924-2937 [Pubmed: 33061806]

Throughput

  • High Throughput

Ontology Terms

  • hacat cell (BTO:0000552) [keratinocyte cell line (BTO:0000375)]
  • keratinocyte (CL:0000312)
  • skin (BTO:0001253)

Curated By

  • BioGRID