BAIT
SCN2A1
6430408L10, A230052E19Rik, Nav1.2, Scn2a, RP23-300F1.1
sodium channel, voltage-gated, type II, alpha 1
GO Process (8)
GO Function (3)
GO Component (12)
Gene Ontology Biological Process
- intrinsic apoptotic signaling pathway in response to osmotic stress [IMP]
- membrane depolarization during action potential [IBA]
- nervous system development [IMP]
- neuron apoptotic process [IMP]
- neuronal action potential [IBA, ISO]
- regulation of ion transmembrane transport [ISO]
- sodium ion transmembrane transport [IDA, ISO]
- sodium ion transport [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ADK
2310026J05Rik, 5033405D03Rik, AI255373, AI987814, Ak
adenosine kinase
GO Process (8)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Experimental and computational evidence that Calpain-10 binds to the carboxy terminus of NaV1.2 and NaV1.6.
Voltage-gated sodium channels (NaV) are pivotal proteins responsible for initiating and transmitting action potentials. Emerging evidence suggests that proteolytic cleavage of sodium channels by calpains is pivotal in diverse physiological scenarios, including ischemia, brain injury, and neuropathic pain associated with diabetes. Despite this significance, the precise mechanism by which calpains recognize sodium channels, especially given the multiple calpain isoforms expressed ... [more]
Sci Rep Mar. 21, 2024; 14(1);6761 [Pubmed: 38514708]
Throughput
- High Throughput
Curated By
- BioGRID