Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.

Publication

EndoMAP.v1 charts the structural landscape of human early endosome complexes.

Gonzalez-Lozano MA, Schmid EW, Miguel Whelan E, Jiang Y, Paulo JA, Walter JC, Harper JW

Early or sorting endosomes are dynamic organelles that play key roles in proteome control by triaging plasma membrane proteins for either recycling or degradation in the lysosome1,2. These events are coordinated by numerous transiently associated regulatory complexes and integral membrane components that contribute to organelle identity during endosome maturation3. Although a subset of the several hundred protein components and cargoes ... [more]

Nature May. 28, 2025; (); [Pubmed: 40437099]

Throughput

High Throughput

Additional Notes

Blue-native polyacrylamide gel co-fractionation-MS (BN-MS)
High confidence protein interactions had a PCProphet score > 0.7 in at least two replicates.

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
AP1G1 AP1G2	Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.	Havugimana PC (2022)	High	-	BioGRID	3432036

Curated By

BioGRID

Interaction Summary

AP1G1

Gene Ontology Biological Process

Gene Ontology Molecular Function

GTP-dependent protein binding [IPI]Rab GTPase binding [IPI]kinesin binding [IPI]protein binding [IPI]transporter activity [TAS]

Gene Ontology Cellular Component

AP1G2