ATP6AP1
Gene Ontology Biological Process
- establishment of organelle localization [ISS]
- pH reduction [ISS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of bone resorption [ISS]
- positive regulation of exocytosis [ISS]
- positive regulation of osteoblast differentiation [ISS]
- positive regulation of osteoclast development [ISS]
- proton transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ATP6V0D1
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- cellular iron ion homeostasis [TAS]
- cellular protein metabolic process [TAS]
- cilium assembly [ISS]
- endoplasmic reticulum unfolded protein response [TAS]
- insulin receptor signaling pathway [TAS]
- interaction with host [TAS]
- phagosome maturation [TAS]
- proton transport [NAS]
- transferrin transport [TAS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
EndoMAP.v1 charts the structural landscape of human early endosome complexes.
Early or sorting endosomes are dynamic organelles that play key roles in proteome control by triaging plasma membrane proteins for either recycling or degradation in the lysosome1,2. These events are coordinated by numerous transiently associated regulatory complexes and integral membrane components that contribute to organelle identity during endosome maturation3. Although a subset of the several hundred protein components and cargoes ... [more]
Throughput
- High Throughput
Additional Notes
- Blue-native polyacrylamide gel co-fractionation-MS (BN-MS)
- High confidence protein interactions had a PCProphet score > 0.7 in at least two replicates.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ATP6AP1 ATP6V0D1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 3348589 | |
| ATP6V0D1 ATP6AP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9236 | BioGRID | 2255945 | |
| ATP6V0D1 ATP6AP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9226 | BioGRID | 3105014 |
Curated By
- BioGRID