Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.

Publication

EndoMAP.v1 charts the structural landscape of human early endosome complexes.

Gonzalez-Lozano MA, Schmid EW, Miguel Whelan E, Jiang Y, Paulo JA, Walter JC, Harper JW

Early or sorting endosomes are dynamic organelles that play key roles in proteome control by triaging plasma membrane proteins for either recycling or degradation in the lysosome1,2. These events are coordinated by numerous transiently associated regulatory complexes and integral membrane components that contribute to organelle identity during endosome maturation3. Although a subset of the several hundred protein components and cargoes ... [more]

Nature May. 28, 2025; (); [Pubmed: 40437099]

Throughput

High Throughput

Additional Notes

Blue-native polyacrylamide gel co-fractionation-MS (BN-MS)
High confidence protein interactions had a PCProphet score > 0.7 in at least two replicates.

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
ESYT2 SRPRB	Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.	Janer A (2024)	High	-	BioGRID	3588921

Curated By

BioGRID

Interaction Summary

ESYT2

Gene Ontology Molecular Function

calcium ion binding [IDA]calcium-dependent phospholipid binding [IDA]identical protein binding [IPI]phosphatidylcholine binding [IDA]phosphatidylethanolamine binding [IDA]phosphatidylinositol binding [IDA]protein binding [IPI]

Gene Ontology Cellular Component

SRPRB

Gene Ontology Biological Process