CDC48
Gene Ontology Biological Process
- ER-associated misfolded protein catabolic process [IMP]
- ER-associated ubiquitin-dependent protein catabolic process [IMP]
- SCF complex disassembly in response to cadmium stress [IMP]
- cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process [IMP]
- endoplasmic reticulum membrane fusion [IMP]
- macroautophagy [IMP]
- mitochondria-associated ubiquitin-dependent protein catabolic process [IMP]
- mitotic spindle disassembly [IMP]
- nonfunctional rRNA decay [IMP]
- nucleus-associated proteasomal ubiquitin-dependent protein catabolic process [IMP]
- piecemeal microautophagy of nucleus [IMP]
- positive regulation of histone H2B ubiquitination [IMP]
- positive regulation of protein localization to nucleus [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- retrograde protein transport, ER to cytosol [IMP]
- ribophagy [IMP]
- ribosome-associated ubiquitin-dependent protein catabolic process [IMP]
- sister chromatid biorientation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Cdc48p-Npl4p-Ufd1p AAA ATPase complex [IDA]
- Cdc48p-Npl4p-Vms1p AAA ATPase complex [IDA]
- Doa10p ubiquitin ligase complex [IDA]
- Hrd1p ubiquitin ligase ERAD-L complex [IDA]
- RQC complex [IDA]
- cytosol [IDA]
- cytosolic large ribosomal subunit [IDA]
- endoplasmic reticulum membrane [IDA]
- mating projection tip [IDA]
- mitochondrion [IDA]
- nucleus [IDA]
RPT1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Cdc48 plays a crucial role in redox homeostasis through dynamic reshaping of its interactome during early stationary phase.
Most microbial cells on earth predominantly exist in non-proliferating, dormant conditions, such as the stationary state. The stationary phase is a crucial stage during the cellular lifespan, which requires homeostatic rewiring for long-term viability and rapid responses to environmental changes. Here, we show that entry to the stationary phase in yeast is accompanied by increased cytosolic and mitochondrial oxidation, imposing ... [more]
Throughput
- High Throughput
Additional Notes
- Cdc48-interacting proteins at 24 hours and 48 hours growth
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RPT1 CDC48 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CDC48 RPT1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.4585 | BioGRID | 1923856 | |
| RPT1 CDC48 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2726 | BioGRID | 1941392 |
Curated By
- BioGRID