BAIT

NSP5

ORF1ab, ORF1ab-nsp5, SARS-CoV2 nsp5, SARS-CoV-2 nsp5, Mpro, 3CLpro, 3C-like proteinase, R1AB_SARS2, PRO_0000449623, GU280_gp01_nsp5
3C-like proteinase; Non-structural protein 5
COVID-19 Coronavirus Project
GO Process (0)
GO Function (0)
GO Component (0)
Severe acute respiratory syndrome coronavirus 2
PREY

FNDC3A

FNDC3, HUGO, bA203I16.1, bA203I16.5, RP11-203I16.5
fibronectin type III domain containing 3A
GO Process (0)
GO Function (1)
GO Component (2)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Protein-peptide

An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.

Publication

Identification of SARS-CoV-2 PLpro and 3CLpro human proteome substrates using substrate phage display coupled with protein network analysis.

Zhao K, Li Y, Guo M, Ma L, Dang B

Viral proteases play key roles in viral replication, and they also facilitate immune escape by proteolyzing diverse target proteins. Deep profiling of viral protease substrates in host cells is beneficial for understanding viral pathogenesis and for antiviral drug discovery. Here, we utilized substrate phage display coupled with protein network analysis to identify human proteome substrates of severe acute respiratory syndrome ... [more]

J Biol Chem Jun. 01, 2023; 299(6);104831 [Pubmed: 37201587]

Throughput

  • High Throughput

Curated By

  • BioGRID