SLC15A3
Gene Ontology Biological Process
Gene Ontology Cellular Component
ADAM10
Gene Ontology Biological Process
- Notch receptor processing [TAS]
- Notch signaling pathway [ISS, TAS]
- PMA-inducible membrane protein ectodomain proteolysis [IMP]
- cell-cell signaling [NAS]
- collagen catabolic process [TAS]
- constitutive protein ectodomain proteolysis [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- in utero embryonic development [ISS]
- integrin-mediated signaling pathway [NAS]
- membrane protein ectodomain proteolysis [IDA, IMP]
- monocyte activation [IMP]
- negative regulation of cell adhesion [IDA, NAS]
- positive regulation of T cell chemotaxis [IMP]
- positive regulation of cell growth [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IMP]
- protein phosphorylation [ISS]
- response to tumor necrosis factor [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- Golgi-associated vesicle [IDA]
- cell surface [IDA]
- cytoplasm [ISS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- integral component of membrane [NAS]
- intracellular membrane-bounded organelle [IDA]
- membrane [IDA]
- nucleus [ISS]
- perinuclear endoplasmic reticulum [IDA]
- plasma membrane [TAS]
- tetraspanin-enriched microdomain [IDA]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The solute carrier superfamily interactome.
Solute carrier (SLC) transporters form a protein superfamily that enables transmembrane transport of diverse substrates including nutrients, ions and drugs. There are about 450 different SLCs, residing in a variety of subcellular membranes. Loss-of-function of an unusually high proportion of SLC transporters is genetically associated with a plethora of human diseases, making SLCs a rapidly emerging but challenging drug target ... [more]
Quantitative Score
- 0.99742164 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- CompPASS and SAINTexpress scores were integrated with quantitative data using a multi-modal RBF classifier (Frommelt et al., Mol. Syst. Biol., 2025, PMID: 40355756).
- HEK 293 Jump-In cells
- PPI probability score = 0.997421639550104
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SLC15A3 ADAM10 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID