BAIT

SLC16A1

HHF7, MCT, MCT1, MCT1D, RP4-580L15.1
solute carrier family 16 (monocarboxylate transporter), member 1
Homo sapiens
PREY

SNX27

MRT1, MY014, RP11-98D18.12-005
sorting nexin family member 27
Alzheimer's Disease Project
Human Papilloma Virus (HPV) Project
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

The solute carrier superfamily interactome.

Frommelt F, Ladurner R, Goldmann U, Wolf G, Ingles-Prieto A, Lineiro-Retes E, Gelova Z, Hopp AK, Christodoulaki E, Teoh ST, Leippe P, Santini BL, Rebsamen M, Lindinger S, Serrano I, Onstein S, Klimek C, Barbosa B, Pantielieieva A, Dvorak V, Hannich TJ, Schoenbett J, Sansig G, Mocking TAM, Ooms JF, IJzerman AP, Heitman LH, Sykacek P, Reinhardt J, Mueller AC, Wiedmer T, Superti-Furga G

Solute carrier (SLC) transporters form a protein superfamily that enables transmembrane transport of diverse substrates including nutrients, ions and drugs. There are about 450 different SLCs, residing in a variety of subcellular membranes. Loss-of-function of an unusually high proportion of SLC transporters is genetically associated with a plethora of human diseases, making SLCs a rapidly emerging but challenging drug target ... [more]

Mol Syst Biol Jun. 01, 2025; 21(6);632-675 [Pubmed: 40355756]

Quantitative Score

  • 0.706173686 [Confidence Score]

Throughput

  • High Throughput

Additional Notes

  • CompPASS and SAINTexpress scores were integrated with quantitative data using a multi-modal RBF classifier (Frommelt et al., Mol. Syst. Biol., 2025, PMID: 40355756).
  • HEK 293 Jump-In cells
  • PPI probability score = 0.706173686493571

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
SNX27 SLC16A1
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High-BioGRID
3379618

Curated By

  • BioGRID