BAIT

SLC19A1

CHMD, FOLT, IFC1, REFC, RFC1
solute carrier family 19 (folate transporter), member 1
GO Process (4)
GO Function (0)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens
PREY

VAMP3

CEB
vesicle-associated membrane protein 3
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

The solute carrier superfamily interactome.

Frommelt F, Ladurner R, Goldmann U, Wolf G, Ingles-Prieto A, Lineiro-Retes E, Gelova Z, Hopp AK, Christodoulaki E, Teoh ST, Leippe P, Santini BL, Rebsamen M, Lindinger S, Serrano I, Onstein S, Klimek C, Barbosa B, Pantielieieva A, Dvorak V, Hannich TJ, Schoenbett J, Sansig G, Mocking TAM, Ooms JF, IJzerman AP, Heitman LH, Sykacek P, Reinhardt J, Mueller AC, Wiedmer T, Superti-Furga G

Solute carrier (SLC) transporters form a protein superfamily that enables transmembrane transport of diverse substrates including nutrients, ions and drugs. There are about 450 different SLCs, residing in a variety of subcellular membranes. Loss-of-function of an unusually high proportion of SLC transporters is genetically associated with a plethora of human diseases, making SLCs a rapidly emerging but challenging drug target ... [more]

Mol Syst Biol Jun. 01, 2025; 21(6);632-675 [Pubmed: 40355756]

Quantitative Score

  • 0.738854514 [Confidence Score]

Throughput

  • High Throughput

Additional Notes

  • CompPASS and SAINTexpress scores were integrated with quantitative data using a multi-modal RBF classifier (Frommelt et al., Mol. Syst. Biol., 2025, PMID: 40355756).
  • HEK 293 Jump-In cells
  • PPI probability score = 0.738854514328727

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
VAMP3 SLC19A1
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High-BioGRID
3374599

Curated By

  • BioGRID