SLC1A1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SLC1A4
Gene Ontology Biological Process
- L-alanine transport [IDA]
- L-cystine transport [IDA]
- L-serine transport [IDA]
- amino acid transport [TAS]
- chloride transmembrane transport [IDA]
- chloride transport [IDA]
- cognition [IMP]
- glutamine transport [TAS]
- hydroxyproline transport [IDA]
- ion transport [TAS]
- proline transmembrane transport [IDA]
- proline transport [IDA]
- synaptic transmission, glutamatergic [NAS]
- threonine transport [IDA]
- transmembrane transport [TAS]
Gene Ontology Molecular Function- L-alanine transmembrane transporter activity [IDA]
- L-cystine transmembrane transporter activity [IDA]
- L-glutamine transmembrane transporter activity [TAS]
- L-hydroxyproline transmembrane transporter activity [IDA]
- L-proline transmembrane transporter activity [IDA]
- L-serine transmembrane transporter activity [IDA]
- L-threonine transmembrane transporter activity [IDA]
- chloride channel activity [IDA]
- L-alanine transmembrane transporter activity [IDA]
- L-cystine transmembrane transporter activity [IDA]
- L-glutamine transmembrane transporter activity [TAS]
- L-hydroxyproline transmembrane transporter activity [IDA]
- L-proline transmembrane transporter activity [IDA]
- L-serine transmembrane transporter activity [IDA]
- L-threonine transmembrane transporter activity [IDA]
- chloride channel activity [IDA]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The solute carrier superfamily interactome.
Solute carrier (SLC) transporters form a protein superfamily that enables transmembrane transport of diverse substrates including nutrients, ions and drugs. There are about 450 different SLCs, residing in a variety of subcellular membranes. Loss-of-function of an unusually high proportion of SLC transporters is genetically associated with a plethora of human diseases, making SLCs a rapidly emerging but challenging drug target ... [more]
Quantitative Score
- 0.978110704 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- CompPASS and SAINTexpress scores were integrated with quantitative data using a multi-modal RBF classifier (Frommelt et al., Mol. Syst. Biol., 2025, PMID: 40355756).
- HEK 293 Jump-In cells
- PPI probability score = 0.978110704182123
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SLC1A1 SLC1A4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3183426 |
Curated By
- BioGRID