SLC22A2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
EXT2
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- cellular polysaccharide biosynthetic process [IDA]
- glycosaminoglycan biosynthetic process [IDA, TAS]
- glycosaminoglycan metabolic process [TAS]
- heparan sulfate proteoglycan biosynthetic process [IMP]
- heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [IMP]
- ossification [IMP]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity [NAS]
- acetylglucosaminyltransferase activity [IDA]
- glucuronosyltransferase activity [IDA]
- heparan sulfate N-acetylglucosaminyltransferase activity [NAS]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- transferase activity, transferring glycosyl groups [IDA]
- N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity [NAS]
- acetylglucosaminyltransferase activity [IDA]
- glucuronosyltransferase activity [IDA]
- heparan sulfate N-acetylglucosaminyltransferase activity [NAS]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- transferase activity, transferring glycosyl groups [IDA]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The solute carrier superfamily interactome.
Solute carrier (SLC) transporters form a protein superfamily that enables transmembrane transport of diverse substrates including nutrients, ions and drugs. There are about 450 different SLCs, residing in a variety of subcellular membranes. Loss-of-function of an unusually high proportion of SLC transporters is genetically associated with a plethora of human diseases, making SLCs a rapidly emerging but challenging drug target ... [more]
Quantitative Score
- 0.44124669 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- CompPASS and SAINTexpress scores were integrated with quantitative data using a multi-modal RBF classifier (Frommelt et al., Mol. Syst. Biol., 2025, PMID: 40355756).
- HEK 293 Jump-In cells
- PPI probability score = 0.441246690208566
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| EXT2 SLC22A2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID