SLC2A1
Gene Ontology Biological Process
- L-ascorbic acid metabolic process [TAS]
- carbohydrate metabolic process [TAS]
- energy reserve metabolic process [TAS]
- glucose transport [IDA, TAS]
- hexose transport [TAS]
- protein complex assembly [IDA]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
- transmembrane transport [TAS]
- vitamin metabolic process [TAS]
- water-soluble vitamin metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CD55
Gene Ontology Biological Process
- CD4-positive, alpha-beta T cell cytokine production [IDA]
- innate immune response [TAS]
- negative regulation of complement activation [IDA]
- positive regulation of CD4-positive, alpha-beta T cell activation [IDA]
- positive regulation of CD4-positive, alpha-beta T cell proliferation [IDA]
- positive regulation of cytosolic calcium ion concentration [IDA]
- regulation of complement activation [TAS]
- regulation of lipopolysaccharide-mediated signaling pathway [IDA]
- respiratory burst [NAS]
- response to virus [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The solute carrier superfamily interactome.
Solute carrier (SLC) transporters form a protein superfamily that enables transmembrane transport of diverse substrates including nutrients, ions and drugs. There are about 450 different SLCs, residing in a variety of subcellular membranes. Loss-of-function of an unusually high proportion of SLC transporters is genetically associated with a plethora of human diseases, making SLCs a rapidly emerging but challenging drug target ... [more]
Quantitative Score
- 0.962537165 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- CompPASS and SAINTexpress scores were integrated with quantitative data using a multi-modal RBF classifier (Frommelt et al., Mol. Syst. Biol., 2025, PMID: 40355756).
- HEK 293 Jump-In cells
- PPI probability score = 0.96253716451629
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CD55 SLC2A1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.822 | BioGRID | 750217 |
Curated By
- BioGRID