BAIT
SLC35B2
PAPST1, SLL, UGTrel4, RP1-302G2.3
solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2
GO Process (11)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- 3'-phospho-5'-adenylyl sulfate transmembrane transport [IDA]
- 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [TAS]
- 3'-phosphoadenosine 5'-phosphosulfate metabolic process [TAS]
- 3'-phosphoadenosine 5'-phosphosulfate transport [IDA]
- carbohydrate metabolic process [TAS]
- glycosaminoglycan metabolic process [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- signal transduction [IMP]
- small molecule metabolic process [TAS]
- transmembrane transport [TAS]
- xenobiotic metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RHBDD1
RRP4, HSD50
rhomboid domain containing 1
GO Process (12)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [ISS]
- cellular response to UV [ISS]
- cellular response to unfolded protein [ISS]
- membrane protein intracellular domain proteolysis [ISS]
- membrane protein proteolysis [IDA]
- negative regulation of apoptotic process [IDA, IMP, ISS]
- positive regulation of protein catabolic process [IDA, IMP]
- positive regulation of protein processing [ISS]
- positive regulation of secretion [IMP]
- post-translational protein modification [ISS]
- regulation of male germ cell proliferation [ISS]
- spermatid differentiation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The solute carrier superfamily interactome.
Solute carrier (SLC) transporters form a protein superfamily that enables transmembrane transport of diverse substrates including nutrients, ions and drugs. There are about 450 different SLCs, residing in a variety of subcellular membranes. Loss-of-function of an unusually high proportion of SLC transporters is genetically associated with a plethora of human diseases, making SLCs a rapidly emerging but challenging drug target ... [more]
Mol Syst Biol Jun. 01, 2025; 21(6);632-675 [Pubmed: 40355756]
Quantitative Score
- 0.49523181 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- CompPASS and SAINTexpress scores were integrated with quantitative data using a multi-modal RBF classifier (Frommelt et al., Mol. Syst. Biol., 2025, PMID: 40355756).
- HEK 293 Jump-In cells
- PPI probability score = 0.495231810290803
Curated By
- BioGRID