SLC7A1
Gene Ontology Biological Process
Gene Ontology Cellular Component
STX4
Gene Ontology Biological Process
- blood coagulation [TAS]
- intracellular protein transport [IBA]
- long-term synaptic potentiation [IDA]
- membrane organization [TAS]
- organelle fusion [IDA]
- platelet activation [TAS]
- positive regulation of catalytic activity [IMP]
- positive regulation of cell adhesion [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of chemotaxis [IMP]
- positive regulation of eosinophil degranulation [IMP]
- positive regulation of establishment of protein localization to plasma membrane [IMP]
- positive regulation of immunoglobulin secretion [IMP]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IDA, IMP]
- positive regulation of protein localization to cell surface [IMP]
- positive regulation of protein localization to plasma membrane [IMP]
- post-Golgi vesicle-mediated transport [TAS]
- regulation of exocytosis [IMP]
- regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- response to hydroperoxide [IDA]
- synaptic vesicle fusion to presynaptic membrane [IBA]
- vesicle docking [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SNARE complex [IDA]
- basolateral plasma membrane [IDA]
- cell surface [IDA]
- cytosol [TAS]
- dendritic spine [IDA]
- endosome [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- integral component of membrane [IBA]
- intracellular [IDA]
- lamellipodium [IDA]
- membrane [IDA]
- plasma membrane [IDA, TAS]
- somatodendritic compartment [IDA]
- specific granule [IDA]
- synapse [IDA]
- synaptic vesicle [IBA]
- vacuole [TAS]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The solute carrier superfamily interactome.
Solute carrier (SLC) transporters form a protein superfamily that enables transmembrane transport of diverse substrates including nutrients, ions and drugs. There are about 450 different SLCs, residing in a variety of subcellular membranes. Loss-of-function of an unusually high proportion of SLC transporters is genetically associated with a plethora of human diseases, making SLCs a rapidly emerging but challenging drug target ... [more]
Quantitative Score
- 0.473843708 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- CompPASS and SAINTexpress scores were integrated with quantitative data using a multi-modal RBF classifier (Frommelt et al., Mol. Syst. Biol., 2025, PMID: 40355756).
- HEK 293 Jump-In cells
- PPI probability score = 0.473843708102442
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SLC7A1 STX4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9936 | BioGRID | 2239055 | |
| SLC7A1 STX4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9921 | BioGRID | 3121600 |
Curated By
- BioGRID