SV2A
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NR2F2
Gene Ontology Biological Process
- intracellular receptor signaling pathway [IDA, TAS]
- lipid metabolic process [TAS]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- negative regulation of endothelial cell migration [IMP]
- negative regulation of endothelial cell proliferation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- regulation of transcription from RNA polymerase II promoter [TAS]
- regulation of transcription involved in lymphatic endothelial cell fate commitment [IMP]
- signal transduction [TAS]
Gene Ontology Molecular Function- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- retinoic acid binding [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IC, IDA]
- transcription corepressor activity [TAS]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- retinoic acid binding [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IC, IDA]
- transcription corepressor activity [TAS]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The solute carrier superfamily interactome.
Solute carrier (SLC) transporters form a protein superfamily that enables transmembrane transport of diverse substrates including nutrients, ions and drugs. There are about 450 different SLCs, residing in a variety of subcellular membranes. Loss-of-function of an unusually high proportion of SLC transporters is genetically associated with a plethora of human diseases, making SLCs a rapidly emerging but challenging drug target ... [more]
Quantitative Score
- 0.534603519 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- CompPASS and SAINTexpress scores were integrated with quantitative data using a multi-modal RBF classifier (Frommelt et al., Mol. Syst. Biol., 2025, PMID: 40355756).
- HEK 293 Jump-In cells
- PPI probability score = 0.534603518679075
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SV2A NR2F2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8842 | BioGRID | 3115609 |
Curated By
- BioGRID