BAIT
SMN
CG16725, DmSMN, Dmel\CG16725, dSMN, l(3)73Ao, Dmel_CG16725
survival motor neuron
GO Process (5)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
PREY
HIS4:CG31611
CG31611, Dmel\CG31611, Dmel_CG31611
CG31611 gene product from transcript CG31611-RA
GO Process (2)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleosome [ISS]
- nucleus [ISS]
Drosophila melanogaster
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic analysis of the SMN complex reveals conserved and etiologic connections to the proteostasis network.
Molecular chaperones and co-chaperones are highly conserved cellular components that perform a variety of duties related to the proper three-dimensional folding of the proteome. The web of factors that carries out this essential task is called the proteostasis network (PN). Ribonucleoproteins (RNPs) represent an underexplored area in terms of the connections they make with the PN. The Survival Motor Neuron ... [more]
Front RNA Res Nov. 04, 2024; 2(); [Pubmed: 39492846]
Throughput
- High Throughput
Additional Notes
- Affinity capture MS was carried out to identify high confidence protein interactors for WT SMN with fold change of greater than equal to 1.5 over control
Curated By
- BioGRID