BAIT
MNB
CG42273, CG7826, CG7835, DYRK1, Dm1, DmDyrk1A, Dmel\CG42273, Dmel_CG7826, Dmel_CG7835, Dyrk1A, ME-IV, min, Dmel_CG42273
minibrain
GO Process (12)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- brain development [IMP, NAS]
- circadian rhythm [IGI]
- learning or memory [NAS]
- nervous system development [IMP]
- olfactory learning [IMP]
- positive regulation of feeding behavior [IMP]
- positive regulation of growth [IMP]
- positive regulation of hippo signaling [IMP]
- positive regulation of synaptic growth at neuromuscular junction [IMP]
- positive regulation of synaptic vesicle endocytosis [IMP]
- protein phosphorylation [NAS]
- visual behavior [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
PREY
CG9684
Dmel\CG9684, Dmel_CG9684
CG9684 gene product from transcript CG9684-RA
GO Process (1)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Regulation of Drosophila brain development and organ growth by the Minibrain/Rala signaling network.
The human dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) is implicated in the pathology of Down syndrome, microcephaly, and cancer; however the exact mechanism through which it functions is unknown. Here, we have studied the role of the Drosophila ortholog of DYRK1A, Minibrain (Mnb), in brain development and organ growth. The neuroblasts (neural stem cells) that eventually give rise ... [more]
G3 (Bethesda) Nov. 06, 2024; 14(11); [Pubmed: 39271109]
Throughput
- High Throughput
Additional Notes
- Affinity capture MS was carried out to identify high confidence protein interactors with a SAINT score (AvgP) greater than or equal to 0.8
- AvgP = 0.9455
Curated By
- BioGRID