BAIT
PRMT3
HRMT1L3
protein arginine methyltransferase 3
GO Process (4)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
P4HB
DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB
prolyl 4-hydroxylase, beta polypeptide
GO Process (8)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- cellular response to hypoxia [IMP]
- extracellular matrix organization [TAS]
- lipoprotein metabolic process [TAS]
- peptidyl-proline hydroxylation to 4-hydroxy-L-proline [IDA]
- protein folding [IBA]
- regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IMP]
- response to endoplasmic reticulum stress [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
PRMT3-mediated arginine methylation of IGF2BP1 promotes oxaliplatin resistance in liver cancer.
Although oxaliplatin-based chemotherapy has been effective in the treatment of hepatocellular carcinoma (HCC), primary or acquired resistance to oxaliplatin remains a major challenge in the clinic. Through functional screening using CRISPR/Cas9 activation library, transcriptomic profiling of clinical samples, and functional validation in vitro and in vivo, we identify PRMT3 as a key driver of oxaliplatin resistance. Mechanistically, PRMT3-mediated oxaliplatin-resistance is ... [more]
Nat Commun Apr. 06, 2023; 14(1);1932 [Pubmed: 37024475]
Throughput
- High Throughput
Curated By
- BioGRID