An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

CPVL promotes glioma progression via STAT1 pathway inhibition through interactions with the BTK/p300 axis.

Yang H, Liu X, Zhu X, Li X, Jiang L, Zhong M, Zhang M, Chen T, Ma M, Liang X, Lv K

CPVL (carboxypeptidase, vitellogenic-like) is a serine carboxypeptidase that was first characterized in human macrophages. However, the function of CPVL remains unclear in a variety of tumors. The quantitative PCR (qPCR), Western blotting, and IHC assays were utilized to measure the CPVL expression. CPVL was significantly upregulated in glioma cells and tissues compared with normal cells and tissues, respectively. Moreover, high ... [more]

JCI Insight Dec. 22, 2021; 6(24); [Pubmed: 34784299]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
FXR2 CPVL	Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.	Youn JY (2018)	High	-	BioGRID	2813970

Curated By

BioGRID

Interaction Summary

CPVL

Gene Ontology Cellular Component

FXR2

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA binding [TAS]identical protein binding [IPI]mRNA binding [IBA]poly(A) RNA binding [IDA]protein binding [IPI]