SKI
Gene Ontology Biological Process
- BMP signaling pathway [TAS]
- SMAD protein signal transduction [IDA]
- anterior/posterior axis specification [ISS]
- bone morphogenesis [ISS]
- camera-type eye development [ISS]
- camera-type eye morphogenesis [ISS]
- cell motility [NAS]
- cell proliferation [NAS]
- embryonic limb morphogenesis [ISS]
- face morphogenesis [ISS]
- gene expression [TAS]
- lens morphogenesis in camera-type eye [ISS]
- myelination in peripheral nervous system [ISS]
- myotube differentiation [IDA]
- negative regulation of BMP signaling pathway [IDA, IMP]
- negative regulation of Schwann cell proliferation [IGI]
- negative regulation of activin receptor signaling pathway [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of fibroblast proliferation [ISS]
- negative regulation of osteoblast differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP, TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA, IGI, IMP]
- neural tube closure [ISS]
- nose morphogenesis [ISS]
- olfactory bulb development [ISS]
- palate development [ISS]
- positive regulation of DNA binding [IDA]
- positive regulation of Wnt signaling pathway [NAS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- protein homotrimerization [IDA]
- regulation of apoptotic process [IBA]
- retina development in camera-type eye [ISS]
- skeletal muscle fiber development [ISS]
- somatic stem cell maintenance [ISS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [NAS, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RANBP9
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A foundational atlas of autism protein interactions reveals molecular convergence
Translating high-confidence (hc) autism spectrum disorder (ASD) genes into viable treatment targets remains elusive. We constructed a foundational protein-protein interaction (PPI) network in HEK293T cells involving 100 hcASD risk genes, revealing over 1,800 PPIs (87% novel). Interactors, expressed in the human brain and enriched for ASD but not schizophrenia genetic risk, converged on protein complexes involved in neurogenesis, tubulin biology, ... [more]
Quantitative Score
- 0.996084058 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- Affinity purification-MS was used to capture high confidence wild-type protein interactors as defined by the thresholds: BFDR <= 0.05 and compPASS scores (rank_WD) >= 0.971. Baits are Strep-tagged proteins exogenously expressed in HEK 293T cells. ComPASS score: 0.996084058
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SKI RANBP9 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8245 | BioGRID | 3288085 | |
| SKI RANBP9 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 1508594 |
Curated By
- BioGRID