BAIT

RNF112

BFP, ZNF179
ring finger protein 112
UPS Project
GO Process (0)
GO Function (1)
GO Component (0)

Gene Ontology Molecular Function

Homo sapiens
PREY

MARK3

CTAK1, KP78, PAR1A, Par-1a
MAP/microtubule affinity-regulating kinase 3
Alzheimer's Disease Project
UPS Project
GO Process (0)
GO Function (2)
GO Component (2)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

RNF112 Facilitates Ubiquitin-Mediated Degradation of c-Myc, Suppressing Proliferation, Migration and Lipid Synthesis in Bladder Cancer.

Xiong K, Chen S, Xu H, Tu S, Weng H, Wang Y, Li M, Yu J, Qian K, Ju L, Zhang Y, Xiao Y, Wang X, Wang G

The E3 ubiquitin ligase RNF112 is significantly downregulated in bladder cancer (BLCA) and is correlated with disease progression. In vitro and in vivo studies indicated that RNF112 suppresses BLCA cell proliferation, migration, and lipid synthesis. Mechanistically, RNF112 directly interacts with the MB II domain of MYC through its N-terminal zinc finger motif, and its catalytic site C97 facilitates K48-linked polyubiquitination ... [more]

Adv Sci (Weinh) May. 01, 2025; 12(20);e2408311 [Pubmed: 40178292]

Throughput

  • High Throughput

Curated By

  • BioGRID