BIRC5
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [IDA]
- cell division [IMP]
- cytokinesis [IMP]
- establishment of chromosome localization [IMP]
- inhibition of cysteine-type endopeptidase activity involved in apoptotic process [IBA]
- mitotic cell cycle [TAS]
- mitotic nuclear division [TAS]
- negative regulation of apoptotic process [IDA, IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA, IMP]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of cell proliferation [TAS]
- positive regulation of exit from mitosis [IMP]
- positive regulation of mitotic cell cycle [IMP]
- protein complex localization [IMP]
- protein phosphorylation [IDA]
- protein ubiquitination [IBA]
- regulation of signal transduction [IBA]
- spindle assembly involved in mitosis [IBA]
- spindle checkpoint [IMP]
Gene Ontology Molecular Function- Ran GTPase binding [IPI]
- chaperone binding [IPI]
- cobalt ion binding [NAS]
- cofactor binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IMP]
- enzyme binding [IPI]
- identical protein binding [IPI]
- microtubule binding [IDA, TAS]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA, IPI]
- tubulin binding [IDA]
- ubiquitin-protein transferase activity [IBA]
- zinc ion binding [IDA, NAS]
- Ran GTPase binding [IPI]
- chaperone binding [IPI]
- cobalt ion binding [NAS]
- cofactor binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IMP]
- enzyme binding [IPI]
- identical protein binding [IPI]
- microtubule binding [IDA, TAS]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA, IPI]
- tubulin binding [IDA]
- ubiquitin-protein transferase activity [IBA]
- zinc ion binding [IDA, NAS]
Gene Ontology Cellular Component
- centriole [IDA]
- chromosome passenger complex [IPI]
- chromosome, centromeric region [IDA]
- condensed chromosome kinetochore [IDA]
- cytoplasm [IDA]
- cytoplasmic microtubule [IDA]
- cytosol [IDA, TAS]
- interphase microtubule organizing center [IDA]
- midbody [IDA]
- nuclear chromosome [IDA]
- nucleus [IDA]
- spindle microtubule [IDA]
TP53BP1
Gene Ontology Biological Process
- DNA repair [TAS]
- cellular response to DNA damage stimulus [IDA]
- double-strand break repair [TAS]
- double-strand break repair via homologous recombination [TAS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IC]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [NAS]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Localization matters: nuclear-trapped Survivin sensitizes glioblastoma cells to temozolomide by elevating cellular senescence and impairing homologous recombination.
To clarify whether differential compartmentalization of Survivin impacts temozolomide (TMZ)-triggered end points, we established a well-defined glioblastoma cell model in vitro (LN229 and A172) and in vivo, distinguishing between its nuclear and cytoplasmic localization. Expression of nuclear export sequence (NES)-mutated Survivin (SurvNESmut-GFP) led to impaired colony formation upon TMZ. This was not due to enhanced cell death but rather due ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BIRC5 TP53BP1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| TP53BP1 BIRC5 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | - | BioGRID | 3410967 |
Curated By
- BioGRID