BAIT
SOCS5
CIS6, CISH6, Cish5, SOCS-5
suppressor of cytokine signaling 5
GO Process (8)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- cell growth [NAS]
- cytokine-mediated signaling pathway [IBA, ISS]
- negative regulation of JAK-STAT cascade [IBA]
- negative regulation of T-helper 2 cell differentiation [ISS]
- negative regulation of epidermal growth factor-activated receptor activity [IDA]
- negative regulation of signal transduction [NAS]
- positive regulation of T-helper 1 cell differentiation [ISS]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
DNAJA1
DJ-2, DjA1, HDJ2, HSDJ, HSJ2, HSPF4, NEDD7, hDJ-2, RP11-54K16.1
DnaJ (Hsp40) homolog, subfamily A, member 1
GO Process (9)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- negative regulation of JUN kinase activity [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of protein ubiquitination [IDA]
- positive regulation of apoptotic process [IMP]
- protein folding [TAS]
- protein localization to mitochondrion [IMP]
- protein refolding [IBA]
- regulation of protein transport [IDA]
- response to unfolded protein [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
SOCS5-RBMX stimulates SREBP1-mediated lipogenesis to promote metastasis in steatotic HCC with HBV-related cirrhosis.
Abnormal lipid metabolism promotes hepatocellular carcinoma (HCC) progression, which engenders therapeutic difficulties owing to unclear mechanisms of the phenomenon. We precisely described a special steatotic HCC subtype with HBV-related cirrhosis and probed its drivers. Hematoxylin-eosin (HE) staining of 245 HCC samples revealed a special HCC subtype (41 cases) characterized by HBV-related cirrhosis and intratumoral steatosis without fatty liver background, defined ... [more]
NPJ Precis Oncol Mar. 01, 2024; 8(1);58 [Pubmed: 38429411]
Throughput
- High Throughput
Curated By
- BioGRID