BIN1
Gene Ontology Biological Process
- lipid tube assembly [ISO]
- muscle cell differentiation [IMP]
- positive regulation of GTPase activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of astrocyte differentiation [ISO]
- positive regulation of endocytosis [ISO]
- regulation of cell cycle arrest [ISO]
- regulation of neuron differentiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SPAST
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Proteomic Characterization of the Alzheimer's Disease Risk Factor BIN1 Interactome.
The gene BIN1 is the second-largest genetic risk factor for late-onset Alzheimer's disease (LOAD). It is expressed in neurons and glia in the brain as cell-type-specific and ubiquitous isoforms. BIN1 is an adaptor protein that regulates membrane dynamics in many cell types. Previously, we reported that BIN1 predominantly localizes to presynaptic terminals in neurons and regulates presynaptic vesicular release. However, ... [more]
Throughput
- High Throughput
Additional Notes
- Enriched proteins from BIN1 TurboID samples (Welch's t-test P<0.05, positive t-test difference with Z-score>1) from mouse brain tissue samples.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SPAST BIN1 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 0.135 | BioGRID | 3499857 |
Curated By
- BioGRID