BIN1
Gene Ontology Biological Process
- lipid tube assembly [ISO]
- muscle cell differentiation [IMP]
- positive regulation of GTPase activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of astrocyte differentiation [ISO]
- positive regulation of endocytosis [ISO]
- regulation of cell cycle arrest [ISO]
- regulation of neuron differentiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DNM2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- cell junction [ISO]
- clathrin-coated endocytic vesicle [ISO]
- coated pit [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- growth cone [ISO]
- microtubule [ISO]
- nucleus [ISO]
- photoreceptor inner segment [IDA]
- postsynaptic membrane [ISO]
- protein complex [ISO]
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Proteomic Characterization of the Alzheimer's Disease Risk Factor BIN1 Interactome.
The gene BIN1 is the second-largest genetic risk factor for late-onset Alzheimer's disease (LOAD). It is expressed in neurons and glia in the brain as cell-type-specific and ubiquitous isoforms. BIN1 is an adaptor protein that regulates membrane dynamics in many cell types. Previously, we reported that BIN1 predominantly localizes to presynaptic terminals in neurons and regulates presynaptic vesicular release. However, ... [more]
Throughput
- High Throughput
Additional Notes
- Enriched proteins from BIN1 TurboID samples (Welch's t-test P<0.05, positive t-test difference with Z-score>1) from mouse brain tissue samples.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BIN1 DNM2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| BIN1 DNM2 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.757 | BioGRID | 2668683 |
Curated By
- BioGRID