NEK1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ALS2
Gene Ontology Biological Process
- endosome organization [IGI, NAS]
- neuron projection morphogenesis [IDA]
- positive regulation of Rab GTPase activity [IDA]
- positive regulation of Rac GTPase activity [IDA]
- positive regulation of Rac protein signal transduction [IC]
- positive regulation of Ran GTPase activity [NAS]
- positive regulation of protein kinase activity [IDA]
- positive regulation of protein serine/threonine kinase activity [IDA]
- regulation of endosome size [IEP]
Gene Ontology Molecular Function- Rab GTPase binding [IDA, NAS]
- Rab guanyl-nucleotide exchange factor activity [IDA]
- Rac guanyl-nucleotide exchange factor activity [IDA]
- Ran guanyl-nucleotide exchange factor activity [NAS]
- guanyl-nucleotide exchange factor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- protein serine/threonine kinase activator activity [IDA]
- Rab GTPase binding [IDA, NAS]
- Rab guanyl-nucleotide exchange factor activity [IDA]
- Rac guanyl-nucleotide exchange factor activity [IDA]
- Ran guanyl-nucleotide exchange factor activity [NAS]
- guanyl-nucleotide exchange factor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- protein serine/threonine kinase activator activity [IDA]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin.
NEK family kinases are serine/threonine kinases that have been functionally implicated in the regulation of the disjunction of the centrosome, the assembly of the mitotic spindle, the function of the primary cilium and the DNA damage response. NEK1 shows pleiotropic functions and has been found to be mutated in cancer cells, ciliopathies such as the polycystic kidney disease, as well ... [more]
Throughput
- High Throughput
Additional Notes
- cisplatin treated cells
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ALS2 NEK1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 2220585 | |
| ALS2 NEK1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3078823 |
Curated By
- BioGRID