BAIT

OLE1

MDM2, stearoyl-CoA 9-desaturase, L000001052, L000001297, YGL055W
Delta(9) fatty acid desaturase; required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
GO Process (1)
GO Function (2)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

NEM1

Nem1-Spo7 phosphatase catalytic subunit NEM1, YHR004C
Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
GO Process (2)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Mga2-mediated transcription supports mitotic nuclear expansion under lipid saturation conditions in stearoyl-CoA desaturase Ole1 mutant.

Cheng YL, Kuan JE, Wang CW, Chen RH

Membrane organelles are dynamic structures that depend on fluid membranes for their integrity and function, with the fluidity primarily derived from loosely packed unsaturated lipids. We investigated how cells respond to lipid saturation and its effect on nuclear dynamics in the budding yeast Saccharomyces cerevisiae. We found that the lipid desaturase mutant ole1-20 upregulates various genes, including OLE1, primarily through ... [more]

Mol Biol Cell Nov. 01, 2025; 36(11);ar144 [Pubmed: 41060802]

Throughput

  • Low Throughput

Ontology Terms

  • nuclear morphology (APO:0000057)

Additional Notes

  • Genetic complex
  • nem1/ ole1/ mga2 triple mutants have increased nuclear surface area and decreased nuclear sphericity compared to ole1/ mga2 double mutants

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
OLE1 NEM1
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.1384BioGRID
1981208
OLE1 NEM1
Synthetic Growth Defect
Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Low-BioGRID
3842184

Curated By

  • BioGRID