BAIT

APN2

ETH1, DNA-(apurinic or apyrimidinic site) lyase APN2, L000004434, YBL019W
Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII
GO Process (1)
GO Function (3)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

RAD52

recombinase RAD52, L000001572, YML032C
Protein that stimulates strand exchange; stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis and UV induced sister chromatid recombination
Saccharomyces cerevisiae (S288c)

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Base excision repair and homologous recombination are required for prevention of a chronic DNA damage response in Saccharomyces cerevisiae.

Nepal Y, Ahmed S, Berry AM, Mahmood A, Holland CL, Lewis LK

The chromosomes within eukaryotic cells experience many types of damage that are generated naturally via endogenous processes. The specific pathways that are most critical for repair of such endogenously produced DNA lesions have not been identified. Previous work revealed that budding yeast mutants deficient in double-strand break repair exhibit a persistent DNA damage checkpoint response leading to chronically high levels ... [more]

DNA Repair (Amst) Dec. 16, 2025; 157();103915 [Pubmed: 41411878]

Throughput

  • Low Throughput

Ontology Terms

  • mitotic cell cycle (APO:0000072)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
APN2 RAD52
Synthetic Growth Defect
Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Low-BioGRID
3849395
APN2 RAD52
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
157609

Curated By

  • BioGRID