RAD17
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
POL30
Gene Ontology Biological Process
- chromatin silencing at silent mating-type cassette [IGI, IMP]
- chromatin silencing at telomere [IMP]
- error-free translesion synthesis [IGI]
- establishment of mitotic sister chromatid cohesion [IGI]
- lagging strand elongation [IDA, IPI]
- leading strand elongation [IDA]
- maintenance of DNA trinucleotide repeats [IGI, IMP]
- meiotic mismatch repair [IGI, IMP]
- mismatch repair [IGI, IMP, IPI]
- mitotic cell cycle [IGI]
- mitotic sister chromatid cohesion [IGI, IPI]
- nucleotide-excision repair [IMP]
- positive regulation of exodeoxyribonuclease activity [IDA]
- positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands [IDA]
- postreplication repair [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
A replication stress safeguard provided by the Elg1 Replication Factor C-like complex.
The Elg1 Replication Factor C-like complex (Elg1-RLC) that functions as a proliferating cell nuclear antigen (PCNA) unloader, is known to be involved in multiple DNA replication/repair-related activities from yeast to humans. By exploiting disassembly prone PCNA mutants, we reveal that Elg1-RLC uses its PCNA unloading activity to counter the DNA-alkylating agent methyl-methanesulfonate (MMS)-mediated slow progression of replication forks (RFs). Despite ... [more]
Throughput
- Low Throughput
Ontology Terms
- vegetative growth (APO:0000106)
- stress resistance (APO:0000080)
- viability (APO:0000111)
Additional Notes
- Genetic complex
- pol30 mutation rescues the growth defect of elg1/ rad17 double mutants exposed to MMS
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAD17 POL30 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -6.489 | BioGRID | 216096 | |
| POL30 RAD17 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2187 | BioGRID | 1960600 |
Curated By
- BioGRID