An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.

Publication

MiR-378a-3p Is Critical for Burkitt Lymphoma Cell Growth.

Niu F, Dzikiewicz-Krawczyk A, Koerts J, de Jong D, Wijenberg L, Fernandez Hernandez M, Slezak-Prochazka I, Winkle M, Kooistra W, van der Sluis T, Rutgers B, Terpstra MM, Kok K, Kluiver J, van den Berg A

MicroRNAs (miRNAs) are small RNA molecules with important gene regulatory roles in normal and pathophysiological cellular processes. Burkitt lymphoma (BL) is an MYC-driven lymphoma of germinal center B (GC-B) cell origin. To gain further knowledge on the role of miRNAs in the pathogenesis of BL, we performed small RNA sequencing in BL cell lines and normal GC-B cells. This revealed ... [more]

Cancers (Basel) Nov. 27, 2020; 12(12); [Pubmed: 33261009]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
AGO2 NELFA	Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.	Cho NH (2022)	High	-	BioGRID	3347648

Curated By

BioGRID

Interaction Summary

AGO2

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA 7-methylguanosine cap binding [IDA]endoribonuclease activity [EXP]endoribonuclease activity, cleaving siRNA-paired mRNA [IDA]poly(A) RNA binding [IDA]protein binding [IPI]siRNA binding [IDA]translation initiation factor activity [NAS]

Gene Ontology Cellular Component

NELFA