An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Knockdown of SUCLG2 inhibits glioblastoma proliferation and promotes apoptosis through LMNA acetylation and the mediation of H4K16la lactylation.

Li W, Zhang Q, Yin H, Li Q, Liu S, Wang J, Yuan G, Pan Y

Glioblastoma (GBM) is the most aggressive primary tumour in the central nervous system, and dynamic clonal evolution and interactions within the microenvironment cause its significant spatiotemporal heterogeneity. These interactions primarily manifest as metabolic reprogramming, mitochondrial dynamic imbalance, and epigenetic remodelling. SUCLG2 has been implicated in the progression of GBM; however, the underlying mechanism is unclear. This study aimed to investigate ... [more]

Cell Death Discov Nov. 17, 2025; 11(1);534 [Pubmed: 41249152]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
SUCLG2 IDH3A	Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.	Wan C (2015)	High	0.1357	BioGRID	1263576

Curated By

BioGRID

Interaction Summary

SUCLG2

Gene Ontology Biological Process

Gene Ontology Molecular Function

succinate-CoA ligase (GDP-forming) activity [NAS]

Gene Ontology Cellular Component

IDH3A